Evers JF, Schmitt S, Scholz M, Duch C (2005) New frontiers in functional neuroanatomy: precise automatic reconstruction from confocal image stacks. Neuroimage 23:1283-1298. J Comp Neurol 422:1-17. J Neurophysiol 102(6):3673-88. J Comp Neurol 403:119-134. (2018) Structural and Molecular Properties of Insect Type II Motor Axon Terminals. Vierk R, Pflueger HJ, Duch C (2009) Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. Here we genetically remove dendrites in Drosophila motoneurons, followed by analysis of functional outcomes. Current project. Pflueger HJ, Duch C, Heidel E (2004) Neuromodulatory octopaminergic neurons and their functions during insect motor behaviour. 55099 Mainz Germany. Hutchinson K, Vonhoff F, Duch C (2014) Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons. mail.uni-mainz.de uses Microsoft HTTPAPI web technologies. J Comp Neurol 450:153-166. Libersat F, Duch C (2002) Morphometric analysis of dendritic remodeling in an identified motoneuron during postembryonic development. J Neurophysiol 93:2331-2342. Homepage. University Medical Center Mainz | 2,450 followers on LinkedIn. Duch C (2006) Form and function of identified insect motoneurons. Corresponding author C. Duch: Institute of Neurobiology, Johannes Gutenberg University of Mainz, Col.‐ Kleinmann Weg 2, 55099 Mainz, Germany. Burkert P, Duch C (2006) Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodeling in Manduca sexta. J Neurosci 37(45):10971-10982. : +49 (0) 6131 / 39 - 21979 Fax: +49 (0) 6131 / 39 - 23 004. Duch C, Levine RB (2000) Remodeling of membrane properties and dendritic architecture accompany the postembryonic conversion of a ‘slow’ into a ‘fast’ motoneuron. 9.00-12.00) Tel. Duch C 2 Affiliations . Meseke M, Evers JF, Duch C (2009) Postembryonic dendritic remodeling of an identified neuron is accompanied by changes in synapse distribution and dendritic input computation. J Exp Biol 202:3555-3564. J Comput Neurosci 34(2):211-29. eBook - JaSeAn. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. Unravel Resilience - Using Multi-Omics Integration to explore the Molecular Background of Stress Resilience Resilience is the ability to cope with stress or to quickly recover to pre-crisis state after being exposed to extreme stress. Duch C, Levine RB (2002) Changes of calcium signaling during postembryonic dendritic growth in Manduca sexta. mail.uni-mainz.de links to network IP address Development 140(3):606-16. E-Mail. Morris OT, Duch C, Stevenson PA (1999) Reflex activation of locust octopaminergic modulatory neurons by proprioreceptors responsive to flight muscle contractions. Williams AA, White R, Sniard A, Corneveaux J, Huentelman M, Duch C (2016) MECP2 impairs neuronal structure by regulating KIBRA. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany. Each neuron must acquire a specific ‘Gestalt’ and a defined set of ion channels during development and maintain them within critical ranges throughout life. Methods: Patients meeting selection criteria (IOP one eye 19 mmHg and ≤32 mmHg and IOP both eyes ≤32 mmHg at 8:00 h) were switched to travoprost monotherapy for 4 weeks. J Exp Biol 198:1963-1976. Acta Biol Hung 51:343-348. (2)Institute of Molecular Biology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany. 1990-1994 Study of Biology, Free University Berlin 1994 Diploma of Biology, Free University Berlin 1995-1998 PhD Student at the Institute of Neurobiology, Free University Berlin doi: 10.1523/ENEURO.0181-19.2019. Lukas Kilo, Ph.D. Student, kilo@uni-mainz.de Dutta S, Rieche F, Eckl N, Duch C, Kretzschmar D (2015) Glial expression of Swiss-Cheese, the Drosophila orthologue of Neuropathy Target Esterase, is required for neuronal ensheathment and function. awiercze@students.uni-mainz.de, anna.wierczeiko@lir-mainz.de. J Comp Neurol, 518:2169-2185. Find more data about mail. doi: 10.1523/ENEURO.0181-19.2019. and the secretary: Renate Bertgen. Ryglewski S, Duch C (2009) Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron. Börner J, Duch C (2010) A standard neuroanatomy atlas for the adult Drosophila ventral nerve cord. eNeuro. Duch C, Mentel T (2003) Motoneuron terminal retraction and outgrowth depend on stage-specific activity patterns during the metamorphosis of Manduca sexta. Brembs B, Christiansen F, Pflueger HJ, Duch C (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. Johannes Gutenberg University Mainz was originally founded in 1477 and today still strives to emulate the innovational spirit of its namesake. When analyzing the role of dendrites, the experimental challenge is to abolish them selectively in identified Drosophila wing motoneurons without affecting other properties of these specific neurons or others. Ryglewski S, Duch C (2012) Preparation of Drosophila Central Neurons for in situ Patch Clamping. Aging (Albany NY). Cell Tissue Res 334:477-498. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.352 55128 Mainz Tel: +49 6131/3923419 Fax: +49 6131/3925443 e-mail: cduch@uni-mainz.de. Stocker B, Bochow C, Damrau C, Mathejczyk T, Wolfenberg H, Colomb J, Weber C, Ramesh N, Duch C, Biserova NM, Sigrist S, Pflüger HJ. Die spätstaufische Burg der Erzbischöfe und Kurfürsten von Mainz wurde um das Jahr 1245 zum Schutz des Gebiets an der Lahnmündung erbaut. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany cduch@uni-mainz.de. Evers JF, Muench D, Duch C (2006) Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia. PNAS 111(50):18049-54. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. Duch C, Mentel T, Pflueger HJ (1999) Distribution and activation of different types of octopaminergic DUM neurons in the locust. J Comp Physiol A: 195(3):265-77. Kuehn C, Duch C (2008) Expression of two different isoforms of fasciclin II during postembryonic central nervous system remodeling in Manduca sexta. Libersat F, Duch C (2004) Cellular and molecular mechanisms of the maturation of neuronal dendritic trees. Pflueger HJ, Duch C (2011) Dynamic neural control of insect muscle metabolism related to motor behavior. Börner J , Puschmann T, Duch C (2006) A steroid hormone affects sodium channel expression in Manduca central neurons. Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the Neuron’s Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage induced PLC and IP3R Activation. ℹ️ mail.uni-mainz.de receives about 38,037 unique visitors per day, and it is ranked 25,698 in the world. J Neurosci 27(41):11122-31. We are interested in the functional diversity of voltage gated calcium channels and its implications for normal neurophysiology ans behavior. Vonhoff F, Kühn C, Blumenstock S°, Sanyal S, Duch C (2013) A precise temporal coherency between receptor expression, neural activity, and AP-1 dependent transcription regulates dendrite development in an identified Drosophila motoneuron. Die Entfernung von Graffiti kostet die Johannes Gutenberg-Universität jährlich rund 80.000 Euro. Burg Lahneck. J Neurosci 15:1109-1113. Mit Erfahrungsberichten, NC-Liste und zulassungsfreien Studiengängen. Email: cduch@uni-mainz.de Search for more papers by this author Therefore, even with a complete connectome in hand, understanding brain function requires an intricate analysis of the physiology and functional morphology of its component neurons. DEGREE COURSE: Guide to the Bachelors and Masters Degree Programs Page-Name:IDN Homepage Last Update:12.October 2017 Disease Models & Mechanisms, Dec 3 [Epub ahead of print]. • determine the functional consequences of correct and false regulation of neuronal properties for synaptic integration, neuronal firing patterns, and behavior in the healthy and in the diseased brain. Consoulas C, Duch C, Bayline RJ, Levine RB (2000) Behavioral transformations during metamorphosis: remodeling of neural and motor systems. Background: To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension. Duch's work group at Mainz University is investigating dendritic structures and functions using the fruit fly Drosophila as a model organism. Mainz é uma cidade independente ( kreisfreie Stadt ) ou distrito urbano ( Stadtkreis ), ou seja, possui estatuto de distrito ( … Pathobiochem., UM Mainz: Carsten Duch Inst. However, in a computing, adapting, and learning system such as the brain, these properties must also retain functional plasticity. Kathryn Scheckel, Carsten Duch Correspondence cduch@uni-mainz.de In Brief Ryglewski et al. Duch C, Mentel T (2004) Activity affects dendritic shape and synapse elimination during steroid induced dendritic regression in Manduca sexta. Duch C, Pflueger HJ (1995) Motor patterns for horizontal and upside down walking and vertical climbing in the locust. J Neurosci 20:6950-6961. PLoS Biol 5(4):e66. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and membrane currents. Exkursion LL BiMA. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Approximately 100 billion neurons in our brain form 100 trillion synapses onto 100,000 miles of dendritic cable. - Fr. Front Syst Neurosci 11:68, Kadas D, Klein A, Krick N, Worrell JW, Ryglewski S, Duch C (2017) Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. The promotion and introduction of new ideas, the use of knowledge to improve people’s lives and encourage them to overcome the many boundaries they encounter daily – these are the underlying ambitions of Johannes Gutenberg University Mainz. Please note: Due to the amount of requests reaching the “Studierendenservice” at the moment there is a delay up to one week in answering them. Duch, Univ.-Prof. Dr. Carsten Address: Hanns-Dieter-Hüsch-Weg 15,55128 Mainz Building: BioZentrum I (1578) Room: 02-352 Phone: +49 6131 39 23419 Mar 19;12:5. doi: 10.3389/fnsys.2018.00005. Institute of Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany. Pflueger HJ, Duch C (2000) The functional role for octopaminergic neurons in insect motor behavior. Toplinks. Herrera-Valdez MA, McKiernan EC*, Berger SD*, Ryglewski S, Duch C, Crook S (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. To understand the adaptive regulation of these properties our research objectives are: • identify the molecular mechanisms that regulate electrical and morphological properties of neurons. Advising by appointment only. Ryglewski S, Vonhoff F, Scheckel K, Duch C (2017) Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material. Acta Biol Hung 55:3-12. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Physiology, UM Mainz: Amparo Acker-Palmer Cell Biology, GU Frankfurt: Eva-Maria Albers Dept. Hohensee S, Bleiss W, Duch C (2008) Correlative electron and confocal microscopy assessment of synapse localization in the central nervous system of an insect. J Neurosci 24:9826-9837. Group (private) – Master of Education, Uni Mainz. Includes free vocabulary trainer, verb tables and pronunciation function. Cell Biology, JGU Mainz: Albrecht Clement Inst. Die rechteckige Kernburg ist von vier Gebäudeflügeln und einer Schildmauer mit Ecktürmen umgeben. Eur J Neurosci 23:335-349. Neurons are the building blocks of the brain. J Comp Physiol A: 196(1):37-50. The University of Mainz (full name Johannes Gutenberg University Mainz) (German: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. 1. J Neurophysiol 102:41-58. eNeuro. The Ernst Florey memory lecture. Group (open) – Master Erziehungswissenschaft, Uni Mainz. J Neurophysiol 100(5):2525-36. Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S*, Duch C* (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. Corresponding Author. Additional information about this page. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. J Neurophysiol 79:361-370. Arbeitsgruppe von der Theorie zur Forschungspraxis. Vonhoff F, Duch C (2010) Tiling Among Stereotyped Dendritic Branches in an Identified Drosophila Motoneuron. J Vis Exp 15;(68). PNAS 116(9):3805-3810. Mainz, Renânia-Palatinado, Alemanha: Presidente Georg Krausch Total de estudantes: 37 039 Página oficial website oficial: A Universidade Johannes Gutenberg de Mainz (em alemão: Johannes Gutenberg-Universität Mainz) é uma instituição de ensino superior localizada em Mainz, no estado da Renânia-Palatinado, Alemanha. Inst. Vierk R, Pflueger HJ, Duch C (2010) Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta. The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. Ryglewski S, Kadas S, Hutchinson K, Schuetzler N, Vonhoff F, Duch C (2014) Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Synapses determine information processing between neurons, whereas electrical properties as well as structure determine information processing within neurons. PLoS One, 7(2):e31835. To address these questions we use Drosophila melanogaster as a model system. Arbeitsgruppe/Research team Prof. Dr. C. Duch. Kadas D, Ryglewski S, Duch C (2015) Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. Neuron 93(3):632-645.e6. Ryglewski S, Kilo L, Duch C (2014) Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron Eur J Neurosci, 39(10):1572-85. Mol Neurobiol 29:303-320. With approximately 32,000 students (2018) in about 100 schools and clinics, it is among the largest universities in Germany. Fax +49 6131 39-25548. J Comp Physiol A 184:489-499. Duch C, Vonhoff F, Ryglewski S (2008) Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability. Vonhoff F, Williams A, Ryglewski S, Duch C (2012) Drosophila as a Model for MeCP2 Gain of Function in Neurons. Ryglewski S, Lance K, Levine RB, Duch C (2012) Cav2 Channels Mediate LVA and HVA Calcium Currents in Drosophila Motoneurons. Accordingly, dendritic defects are consistent anatomical correlates of numerous brain diseases, but specific causality remains unproven. J Neurosci Methods 15:168(1):64-70. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. Look up the English to German translation of uni Mainz in the PONS online dictionary. Physiology (Bethesda) 26:293-303. Meseke M, Evers JF, Duch C (2009) PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development. Perturbations cause dendrite shifts and result in defects of adaptive motor control. In addition to the unprecedented genetic tools available in Drosophila, the transformation from the larval to the adult stage during metamorphosis is a striking example of postembryonic nervous system plasticity and remodeling, and the functions of individually identified neurons can directly be related to stage specific behaviors. European J Neurosci 17:1-18. Neurons are the building blocks of the brain. Uni Mainz. J Neurophysiol 87:1415-1425. Stefanie Ryglewski, Ph.D., ryglewsk@uni-mainz.de. Close affiliations . Bayline RJ, Duch C, Levine RB (2001) Nerve-muscle interactions regulate motor terminal growth and myoblast distribution during muscle development. E-mail: sac@unieducar.org.br Fone: 0800.005.3005 Escritório em São Paulo - SP: Av. Group leader. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.356 D 55128 Mainz Mo. Mol. Brain Res Bulletin 53:571-583. Besucheranschrift / Office: Hanns-Dieter-Hüsch-Weg 15 (Gebäude 1578, 2.Stock, 02-352) 55128 Mainz 11(6):1850-1873. doi: 10.18632/aging.101880. www.uni-mainz.de. Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. J Physiol 593(22):4871-88. Mentel T, Duch C, Müller U, Stypa H, Wegener G, Pflueger HJ (2003) Fuel selection in locust flight muscle by the activity of central modulatory neurons. Wären Kameras an besonders betroffenen Stellen … Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and … Cell Tissue Res 325:175-87. Group (closed) – BA Erziehungswissenschaften, Uni Mainz. Duch C, Pflueger HJ (1999) DUM neurons in locust flight: a model system for amine mediated peripheral adjustments to a central motor program. report that competitive mechanisms are required to correctly partition synaptic inputs from different transmitter systems on the dendritic arbor of a Drosophila motoneuron. However, the mechanisms and cellular targets of TA modulation of locomotor activity are incompletely understood. Schmitt S, Evers JF, Scholz M, Duch C, Obermayer K (2004) New methods for the computer assisted 3D reconstruction of neurons from confocal image stacks. Ryglewski S, Duch C, Altenhein B (2017) Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. Baudoux S, Duch C, Morris OT (1998) Coupling of efferent neuromodulatory neurons to rhythmical leg motor activity in the locust. Mainz [1] [2] [3] ou Mogúncia [4] [5] (em alemão: Mainz, em latim: Mogontiacum, em francês: Mayence) é uma cidade da Alemanha, capital do estado federal de Renânia-Palatinado. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. Eur J Neurosci, 37(6):860-75. Kühn C, Duch C (2013) Putative Excitatory and Putative Inhibitory Inputs Localize to Different Dendritic Domains in a Drosophila Flight Motoneuron. J Neurosci 34(5):1924-31. We use the versatile genetic model system Drosophila melanogaster for our research. Neurobiol of Disease, in press. Proceedings of the National Academy of … Nove de Julho, 5229 - 5° Andar eCollection 2018. Fields L, Duch C, Pflueger HJ (2007) Reflex activation of octopaminergic unpaired median neurons in the locust. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. J Insect Physiol 54(1):240-54. Int Comp Biol 46:E36. (3)Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; ryglewsk@uni-mainz.de cduch@uni-mainz.de. J Physiol J Physiol 590(Pt 4):809-25. Front Syst Neurosci. 2. Somos uma instituição de Educação que atua nas áreas de Treinamento em Desenvolvimento Profissional e Gerencial desde fevereiro de 2003. E-Mail: joerg.korff@uni-mainz… Johannes Gutenberg-Universität Mainz Jakob-Welder-Weg 9 55099 Mainz. Dev Biol 297(1):214-227. Hotline +49 6131 39-22122. * Shared last author. Adrenergic signaling profoundly modulates animal behavior. J Comp Physiol 195(5):473-89. Dev Biol 231:348-363. J Comp Neurol, 518:2437-2455. Prof. Dr. Carsten Duch. Alles zur Johannes-Gutenberg-Universität Mainz und ihren 204 Studiengängen. Raum 01-230 (Gebäude Recht und Wirtschaft I) Tel. Duch C, Bayline RJ, Levine RB (2000) Development of the DLM flight motor system in Manduca sexta.